Interair South Africa is an airline based in Johannesburg, South Africa. It operates scheduled passenger services from Johannesburg to regional destinations. Its main base is OR Tambo International Airport, Johannesburg.

Interair South Africa operates services to the following international scheduled destinations: Ndola, Zambia; St Denis, Réunion Island; Antananarivo, Madagascar; ;Libreville, Gabon; Brazzaville, Republic of the Congo; Cotonou, Benin, Ougadougou, Burkina Faso, Bamako, Mali, N'djamena, Chad.

The Interair South Africa fleet includes the following aircraft: 3 Boeing 737-200 and 1 Fokker F28 Mk4000.